A genome-wide association study identifying SVEP1 variant as a predictor of response to tolvaptan for cirrhotic ascites.
Hideto KawarataniHiromi SawaiMasaya OnishiTomomi KogisoNoritomo ShimadaHaruki UojimaTomoaki NakajimaNaoki MatsumotoKenichi IkejimaToru IshikawaShuji TeraiHiroyuki MotoyamaAtsumasa KomoriNoboru HirashimaSatoru SaitoYuichiro EguchiMasanori NojimaYosuke KawaiMasakuni TateyamaHitoshi YoshijiYasuhito TanakaPublished in: Liver international : official journal of the International Association for the Study of the Liver (2021)
SVEP1 rs2991364 was identified as the specific SNP for the tolvaptan response. The prediction score (>38.6%) can identify tolvaptan non-responders and help to avoid a lengthy period of futile treatment.