Discovery and 3D imaging of a novel ΔNp63-expressing basal cell type in human pancreatic ducts with implications in disease.

Sandrina Martens Katarina Coolens Mathias Van Bulck Tatjana ArsenijevicJoan CasamitjanaAngel Fernandez RuizAbdessamad El KaoutariJaime Martinez de VillarealHediel Madhloum Farzad EsniYves HeremansGunter Leuckx Harry Heimberg Luc Bouwens Patrick Jacquemin Diedert Luc De Paep Peter In't Veld Nicky D'haene Christelle Bouchart Nelson J Dusetti Jean-Luc Van Laethem Wim WaelputPierre LefesvreFrancisco X Real Meritxell Rovira Ilse Rooman

Published in: Gut (2021)

In larger human pancreatic ducts, basal cells exist. ΔNp63 suppresses duct cell identity. These cells may play an important role in pancreatic disease, including PDAC ontogeny, but are not present in mouse models.

Keyphrases

induced apoptosis
endothelial cells
cell cycle arrest
mouse model
signaling pathway
induced pluripotent stem cells
endoplasmic reticulum stress
single cell
high resolution
cell proliferation
pi k akt
mesenchymal stem cells