Cancer-cell-secreted CXCL11 promoted CD8+ T cells infiltration through docetaxel-induced-release of HMGB1 in NSCLC.

Qun GaoShumin WangXinfeng ChenShaoyan ChengZhen ZhangFeng LiLan HuangYang YangBin ZhouDongli YueDan WangLing CaoNomathamsanqa Resegofetse MaimelaBin ZhangJane YuLiping WangYi Zhang

Published in: Journal for immunotherapy of cancer (2019)

Our results demonstrate that DOC induces CD8+ T cell recruitment to the tumor microenvironment by enhancing the secretion of HMGB1 and CXCL11, thus improving the anti-tumor efficacy, indicating that modulating the HMGB1-CXCL11 axis might be helpful for NSCLC treatment.

Keyphrases

small cell lung cancer
advanced non small cell lung cancer
diabetic rats
high glucose
brain metastases
squamous cell carcinoma
oxidative stress
locally advanced
endothelial cells
radiation therapy
epidermal growth factor receptor
rectal cancer
replacement therapy
tyrosine kinase