Single-cell characterisation of tissue homing CD4 + and CD8 + T cell clones in immune-mediated refractory arthritis.
Dipabarna BhattacharyaJason TheodoropoulosKatariina NurmiTimo JuutilainenKari K EklundRiitta KoivuniemiTiina KelkkaSatu MustjokiTapio LönnbergPublished in: Molecular medicine (Cambridge, Mass.) (2024)
Our findings suggest that the local environment in the synovium drives the proliferation of activated cytotoxic T cells, and both CD4 + and CD8 + T cells may contribute to tissue destruction and disease pathogenesis.