Prehospital immune responses and development of multiple organ dysfunction syndrome following traumatic injury: A prospective cohort study.
Jon HazeldineDavid N NaumannEmma TomanDavid DaviesJonathan R B BishopZhangjie SuPeter HampsonRobert J DinsdaleNicholas CrombieNiharika Arora DuggalPaul HarrisonAntonio BelliJanet M LordPublished in: PLoS medicine (2017)
Our study highlighted the dynamic and complex nature of the immune response to trauma, with immune alterations consistent with both activation and suppression evident within 1 hour of injury. The relationship of these changes, especially in NKT cell numbers, to patient outcomes such as MODS warrants further investigation.