Four New Polyprenylated Acylphloroglucinols from Hypericum perforatum L.
Xiaoying WangWuyang LiuSheng ChenYueshan GaoJun-Mian TianJinming GaoPublished in: Molecules (Basel, Switzerland) (2024)
Hyperforatums A-D ( 1 - 4 ), four new polyprenylated acylphloroglucinols, together with 13 known compounds were isolated and identified from the aerial parts of Hypericum perforatum L. (St. John's wort). Their structures were confirmed with a comprehensive analysis comprising spectroscopic methods, including 1D and 2D NMR, HRESIMS, and electronic circular dichroism (ECD) calculations. Hyperforatum A featured an unusual chromene-1,4-dione bicyclic system, and hyperforatums B and C were two rare monocyclic PPAPs with five-membered furanone cores. Compound 1 exhibited a moderate inhibition effect on NO production in BV-2 microglial cells stimulated by LPS.
Keyphrases
- inflammatory response
- lipopolysaccharide induced
- lps induced
- induced apoptosis
- high resolution
- cell cycle arrest
- magnetic resonance
- molecular docking
- molecular dynamics simulations
- molecular dynamics
- density functional theory
- signaling pathway
- endoplasmic reticulum stress
- oxidative stress
- cell death
- anti inflammatory
- pi k akt
- monte carlo