Evolvulins I and II, Resin Glycosides with a Trihydroxy Aglycone Unit from Evolvulus alsinoides.

Bo-Yi FanYun LuMin YangJian-Lin LiGuang-Tong Chen

Published in: Organic letters (2019)

Evolvulins I and II (1 and 2), representing a new class of resin glycosides with an unprecedented trihydroxy aglycone unit, 3S,11R,14R-trihydroxyhexadecanoic acid (4), were isolated from the whole plants of Evolvulus alsinoides. Their structures were thoroughly characterized by extensive spectroscopic analyses as well as chemical evidence. Compound 1 exhibited the most potent cytotoxic activity against MCF-7 cells, with an IC50 value of 3.12 μM.

Keyphrases

induced apoptosis
cell cycle arrest
molecular docking
breast cancer cells
high resolution
cell death
oxidative stress
cell proliferation
mass spectrometry
pi k akt