Depressive symptom-associated IL-1β and TNF-α release correlates with impaired bronchodilator response and neutrophilic airway inflammation in asthma.
Li ZhangXin ZhangJing ZhengYing LiuJi WangGang WangHong Ping ZhangDe Ying KangZu Gui PengYu Lin JiLei WangPeter Gerard GibsonGang WangPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2019)
Asthma patients with depressive symptoms present worse asthma control, which is most likely explained by impaired BDR and neutrophilic airway inflammation. IL-1β and TNF-α, which are two key pro-inflammatory cytokines that mediate the correlation of depressive symptoms with impaired BDR and neutrophilic airway inflammation, may serve as targeted biomarkers in the neuropsychological phenotype of asthma; however, this result needs to be further validated.