Glial fibrillary acidic protein in cerebrospinal fluid of patients with spinal muscular atrophy.
Maren FreigangPetra SteinackerClaudia D WursterOlivia Schreiber-KatzAlma OsmanovicSusanne PetriJan C KochKevin RostásyAndré HussHayrettin TumaniBenedikt WinterBjörn FalkenburgerAlbert C LudolphMarkus OttoAndreas HermannRené GüntherPublished in: Annals of clinical and translational neurology (2022)
cGFAP is not an outstanding biomarker in SMA, but might support the hypothesis that glial activation is involved in SMA pathology. Unlike previously suggested, cNfL may be a promising biomarker also in adult patients with SMA, which should be subject to further investigations.