Differences in olfactory functional connectivity in early-onset depression and late-onset depression.

Ben ChenMingfeng YangMeiling LiuQiang WangHuarong ZhouMin ZhangLe HouZhangying WuSi ZhangGaohong LinXiaomei ZhongYu-Ping Ning

Published in: Psychoradiology (2023)

Overall, patients with LOD exhibited decreased FC in both the primary and secondary olfactory cortices compared with patients with EOD, and abnormal olfactory FC was associated with OI dysfunction and cognitive impairment. The FC between the orbital-frontal cortex and amygdala mediated the relationship between global cognitive function and OI.

Keyphrases

functional connectivity
late onset
early onset
resting state
cognitive impairment
depressive symptoms
sleep quality
oxidative stress
stress induced