Low Irritation Potential of Tazarotene 0.045% Lotion: Head-to-Head Comparison to Adapalene 0.3% Gel and Trifarotene 0.005% Cream in Two Studies.

In two head-to-head studies comparing the irritation potential of third- and fourth-generation retinoids, tazarotene 0.045% lotion was significantly less irritating than trifarotene 0.005% cream and numerically less irritating than adapalene 0.3% gel.