KRAS mutations in implant-associated peripheral giant cell granuloma.

Roberta Rayra Martins Chaves Letícia Martins Guimarães Thaís Dos Santos Fontes Pereira Nubia Braga Pereira Bruno Ramos Chrcanovic Flávia Sirotheau Correa Pontes Irene Lafuente-Ibáñez de Mendoza José Manuel Aguirre-Urizar Carolina Cavaliéri Gomes Hélder Antônio Rebelo Pontes

Published in: Oral diseases (2019)

KRAS mutations and activation of the MAPK-ERK signaling pathway occur in IA-PGCG. This is the first study to demonstrate cancer-associated gene mutations in a non-neoplastic reactive condition associated with dental implants.

Keyphrases

signaling pathway
pi k akt
giant cell
epithelial mesenchymal transition
induced apoptosis
wild type
cell proliferation
oxidative stress
soft tissue