An antioxidant boehmite amino-nanozyme able to disaggregate Huntington's inclusion bodies.

Álvaro Martínez-CamarenaMarian MerinoAna Virginia Sánchez-SánchezSalvador Blasco José M LlinaresJosé L MullorEnrique Garcı A-España

Published in: Chemical communications (Cambridge, England) (2022)

A novel amino-nanozyme, based on boehmite nanoparticles (BNPs) functionalised with a tetra-azapyridinophane (L1), has been designed to undermine some of the key issues underlying Huntington disease. L1 forms Cu 2+ complexes with a striking SOD activity, while when grafted to the BNPs displays mitoROS scavenging properties and ability to disaggregate mutant huntingtin deposits in cells.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
anti inflammatory
cell death
signaling pathway
wild type
pi k akt