Escalated complement activation during hospitalization is associated with higher risk of 60-day mortality in SARS-CoV-2-infected patients.

Andreas Barrat-DueKristin PettersenTuva Børresdatter-DahlJan Cato HolterRenathe H GrønliAnne Ma Dyrhol-RiiseTøri Vigeland LerumAleksander Rygh HoltenKristian TonbyMarius TrøseidOle H SkjønsbergBeathe Kiland GranerudLars HeggelundAnders Benjamin KildalCamilla SchjalmTrond Mogens AaløkkenPål AukrustThor UelandTom Eirik MollnesBente Halvorsennull null

Published in: Journal of internal medicine (2024)

Hospitalized COVID-19 patients display prominent and long-lasting systemic complement activation. Optimal targeting of the system may be achieved through enhanced risk stratification and closer monitoring of in-hospital changes of complement activation products.

Keyphrases

sars cov
healthcare
emergency department
type diabetes
respiratory syndrome coronavirus
cardiovascular disease
coronary artery disease
acute care
electronic health record