Simultaneous Manifestation of Chronic Myelomonocytic Leukemia and Multiple Myeloma during Treatment by Prednisolone and Eltrombopag for Immune-Mediated Thrombocytopenic Purpura.
Masao HagiharaMorihiro InoueKenichiro KodamaTomoyuki UchidaJian HuaPublished in: Case reports in hematology (2016)
An 80-year-old man was admitted to our hospital because of severe thrombocytopenia. He was diagnosed with idiopathic thrombocytopenia, and prednisolone together with eltrombopag was started, leading to significant improvement of platelet counts. Four years later, there was a prominent increase of peripheral blood monocytes, which was accompanied by recurrence of thrombocytopenia. Bone marrow aspirates and serum electrophoresis revealed coexistence of chronic myelomonocytic leukemia (CMML) and multiple myeloma (MM). The patient received lenalidomide plus dexamethasone therapy but died due to exacerbation of the disorder. It was supposed that thrombocytopenia was secondarily caused by CMML and MM developed at a later period.
Keyphrases
- multiple myeloma
- peripheral blood
- bone marrow
- acute myeloid leukemia
- mesenchymal stem cells
- chronic obstructive pulmonary disease
- healthcare
- low dose
- high dose
- case report
- drug induced
- stem cells
- stem cell transplantation
- acute respiratory distress syndrome
- newly diagnosed
- acute care
- cell therapy
- electronic health record