Digital Twins of Acute Hypoxemic Respiratory Failure Patients Suggest a Mechanistic Basis for Success and Failure of Noninvasive Ventilation.

Liam WeaverHossein ShamohammadiSina SaffaranRoberto TonelliMarianna LaviolaJohn G LaffeyLuigi CamporotaTimothy E ScottJonathan G HardmanEnrico CliniDeclan G Bates

Published in: Critical care medicine (2024)

In digital twins of AHRF patients, successful NIV improved lung mechanics, lowering respiratory effort and indices associated with lung injury. NIV failed in patients for whom only low levels of positive inspiratory pressure support could be applied without risking patient self-inflicted lung injury due to excessive tidal volumes.

Keyphrases

respiratory failure
end stage renal disease
newly diagnosed
prognostic factors
peritoneal dialysis
patient reported outcomes
liver failure
body mass index
intensive care unit
weight gain
weight loss
carbon dioxide