Glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors for the treatment of diabetes mellitus in liver transplant recipients.
Katina ZhengAmirhossein AzhieXiaoting YouMaryam NaghibzadehEunice TanSara NaimimohassesVikas Srinivasan SridharSarang GuptaShiyi ChenSatya DashCynthia TsienNazia SelznerLeslie LillyElmar JaeckelMinna WooSunita SinghDavid CherneyMamatha BhatPublished in: Diabetes, obesity & metabolism (2024)
We found that GLP-1RAs, SGLT2 inhibitors, and their combination, led to significant weight loss in LT recipients with diabetes. Combination therapy, in particular, lowered HbA1c and alanine aminotransferase levels compared to DPP-4 inhibitors. Further studies are needed to assess long-term safety and efficacy.