tRNA modification enzyme-dependent redox homeostasis regulates synapse formation and memory.
Kimberly R MadhwaniShanzeh SayiedCarlson H OgataCaley A HoganJenna M LentiniMoushami MallikJennifer L DumouchelErik StorkebaumDragony FuKate M Oâ Connor-GilesPublished in: bioRxiv : the preprint server for biology (2023)
, we link tRNA methyltransferase-regulated selenoprotein synthesis to synapse development and associative memory. These findings demonstrate the key role of tRNA modifiers in redox homeostasis during nervous system development and highlight the potential therapeutic benefit of antioxidant-based therapies for cognitive disorders linked to dysregulation of tRNA modification.