What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline?

Georgina NakaferoMatthew J GraingeTim CardChristian D MallenWeiya ZhangMichael DohertyMaarten W TaalGuruprasad P AithalAbhishek Abhishek

Published in: Rheumatology (Oxford, England) (2021)

MTX and LEF were discontinued for blood-test abnormalities after year 1 of treatment, however, discontinuations for severely abnormal results were uncommon.

Keyphrases

high dose
drug induced