Thalamic atrophy moderates associations among aerobic fitness, cognitive processing speed, and walking endurance in persons with multiple sclerosis.
Brian M SandroffRobert W MotlCristina A F RománGlenn R WylieJohn DeLucaGary R CutterRalph H B BenedictMichael G DwyerRobert ZivadinovPublished in: Journal of neurology (2022)
This study provides initial evidence of strong, selective associations among aerobic fitness, cognitive processing speed, and walking endurance in persons with TA as a biomarker for MS-related neurodegeneration. Such data support TA as a moderator of the association among aerobic fitness, cognitive processing speed, and walking endurance in persons with MS. Future research should carefully consider the role of TA when designing trials of aerobic exercise, cognition, and mobility in MS.