TMSOTf-Promoted Cyclization of Indole-2-methyl-α-aminoketones: Access to 4-Aryl-Substituted β-Carbolines.

Published in: Organic letters (2024)

An efficient method to construct 4-aryl-substituted β-carbolines from indole-2-methyl-α-aminoketones via a TMSOTf-promoted annulation reaction was reported. High yield along with wide substrate scope and functional group tolerance make this reaction applicable to build various highly potential bioactive β-carboline derivatives.

Keyphrases

molecular docking
human health
risk assessment
molecular dynamics simulations
structure activity relationship
structural basis