Stem cell- and gene-based therapies as potential candidates in Alzheimer's therapy.
Seyede Atefe HosseiniRezvan MohammadiSomaye NoruziYousef MohamadiMitra AzizianSeyed Mojta MousavyFaezeh GhasemiAmirReza HesariAmirhossein SahebkarReza SalariniaArad Mobasher AghdamHamed MirzaeiPublished in: Journal of cellular biochemistry (2018)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, which is associated with impairments of memory, thinking, language, and reasoning. Despite extensive research aiming at the treatment of AD, durable and complete remissions are rare. Hence, new therapeutic approaches are required. Among various therapeutic approaches, stem cells (ie, neural stem cells, mesenchymal stem cells, and embryonic stem cells) and delivery of protective genes such as encoding nerve growth factor, APOE, and glial cell-derived neurotrophic factor have generated promise in AD therapy. Here, we summarized a variety of effective therapeutic approaches (ie, stem cells, and genes) in AD therapy.
Keyphrases
- stem cells
- growth factor
- mesenchymal stem cells
- genome wide
- cell therapy
- cognitive decline
- embryonic stem cells
- neural stem cells
- genome wide identification
- autism spectrum disorder
- dna methylation
- gene expression
- spinal cord
- spinal cord injury
- machine learning
- mild cognitive impairment
- climate change
- bone marrow
- neuropathic pain
- bioinformatics analysis
- smoking cessation
- peripheral nerve