Light amplified oxidative stress in tumor microenvironment by carbonized hemin nanoparticles for boosting photodynamic anticancer therapy.
Liyun LinWen PangXinyan JiangShihui DingXunbin WeiBobo GuPublished in: Light, science & applications (2022)
Photodynamic therapy (PDT), which utilizes light excite photosensitizers (PSs) to generate reactive oxygen species (ROS) and consequently ablate cancer cells or diseased tissue, has attracted a great deal of attention in the last decades due to its unique advantages. However, the advancement of PDT is restricted by the inherent characteristics of PS and tumor microenvironment (TME). It is urgent to explore high-performance PSs with TME regulation capability and subsequently improve the therapeutic outcomes. Herein, we reported a newly engineered PS of polymer encapsulated carbonized hemin nanoparticles (P-CHNPs) via a facile synthesis procedure for boosting photodynamic anticancer therapy. Solvothermal treatment of hemin enabled the synthesized P-CHNPs to enhance oxidative stress in TME, which could be further amplified under light irradiation. Excellent in vitro and in vivo PDT effects were achieved due to the improved ROS (hydroxyl radicals and singlet oxygen) generation efficiency, hypoxia relief, and glutathione depletion. Moreover, the superior in vitro and in vivo biocompatibility and boosted PDT effect make the P-CHNPs a potential therapeutic agent for future translational research.
Keyphrases
- photodynamic therapy
- reactive oxygen species
- oxidative stress
- dna damage
- fluorescence imaging
- cancer therapy
- cell death
- ischemia reperfusion injury
- working memory
- diabetic rats
- endothelial cells
- minimally invasive
- current status
- stem cells
- adipose tissue
- walled carbon nanotubes
- weight loss
- mesenchymal stem cells
- glycemic control