Retinoschisis and Norrie disease: a missing link.

Rahini RajendranDhandayuthapani SudhaSubbulakshmi ChidambaramHemavathy NagarajanUmashankar VetrivelJayamuruga Pandian Arunachalam

Published in: BMC research notes (2021)

Co-immunoprecipitation demonstrated lack of a direct interaction between RS1 and NDP and was further substantiated by mass spectrometry. However, STRING revealed a potential indirect functional association between the two proteins. Progressively, our analyses indicate that FZD4 protein interactome via PLIN2 as well as the MAP kinase signaling pathway to be a likely link bridging the functional relationship between retinoschisis and Norrie disease.

Keyphrases

mass spectrometry
signaling pathway
pi k akt
epithelial mesenchymal transition
risk assessment
protein protein
induced apoptosis
binding protein
climate change
ms ms