Integration of a highly monodisperse covalent organic framework photosensitizer with cation exchange synthesized Ag2Se nanoparticles for enhanced phototherapy.

COF-Ag2Se nanoparticles were successfully synthesized under mild conditions via a cation exchange approach using COF and CuSe as templates. The in vitro and in vivo experiments verified the excellent cancer cell killing effect and antitumor efficacy of COF-Ag2Se nanoparticles via combined photodynamic and photothermal therapy.