Faecal metabolome and its determinants in inflammatory bowel disease.
Arnau Vich VilaShixian HuSergio Andreu-SánchezValerie CollijBernadien H JansenHannah E AugustijnLaura A BolteRenate A A A RuigrokGaleb Abu-AliCosmas GiallourakisJessica SchneiderJohn ParkinsonAmal Al-GarawiAlexandra ZhernakovaRanko GacesaJingyuan FuRinse K WeersmaPublished in: Gut (2023)
In this large-scale analysis, we identified alterations in the metabolome of patients with IBD that are independent of commonly overlooked confounders such as diet and surgical history. Considering the influence of the microbiome on faecal metabolites, our results pave the way for future interventions targeting intestinal inflammation.