Midbrain lesion-induced disconjugate gaze: a unifying circuit mechanism of ocular alignment?
Maximilian U FriedrichLaurin SchappeSashank PrasadHelen FriedrichMichael D FoxAndreas ZwergalDavid S ZeeKlaus FaßbenderKlaus-Ulrich DillmannPublished in: Journal of neurology (2024)
A circumscribed region in the dorsal midbrain appears to be a key node for disconjugate eye movements in both vertical and horizontal planes. Lesioning this area produces a unique ocular motor syndrome mirroring hallmarks of developmental strabismus and nystagmus. Further circuit-level studies could offer pivotal insights into shared pathomechanisms of acquired and developmental disorders affecting eye alignment.