Alteration of gene expression in reactive astrocytes induced by Aβ1-42 using low dose of methamphetamine.

The pure form of METH can prevent from activating GSK-3β and CdK-5, as well as enhanced activity of PKCα to inhibit phosphorylated tau protein. Therefore, a low dose of METH may have a protective effect or reducing role in the pathway of tau production in reactive astrocytes.