The AORTA Gene score for detection and risk stratification of ascending aortic dilation.
James Paul PirruccelloShaan KhurshidHonghuang LinLu-Chen WengSiavash ZamirpourShinwan KanyAvanthi RaghavanSatoshi KoyamaRamachandran S VasanEmelia J BenjaminMark E LindsayPatrick T EllinorPublished in: European heart journal (2024)
A comprehensive model incorporating polygenic information and clinical risk factors explained 34.9%-41.8% of the variation in ascending aortic diameter, improving the identification of ascending aortic dilation and adverse thoracic aortic events compared to clinical risk factors.
Keyphrases
- aortic dissection
- pulmonary artery
- aortic valve
- risk factors
- coronary artery
- pulmonary hypertension
- pulmonary arterial hypertension
- left ventricular
- spinal cord
- healthcare
- spinal cord injury
- gene expression
- atrial fibrillation
- optic nerve
- loop mediated isothermal amplification
- label free
- genome wide identification
- adverse drug