A smart mask for exhaled breath condensate harvesting and analysis.
Wenzheng HengShukun YinJihong MinCanran WangHong HanEhsan Shirzaei SaniJiahong LiYu SongHarry B RossiterWei GaoPublished in: Science (New York, N.Y.) (2024)
Recent respiratory outbreaks have garnered substantial attention, yet most respiratory monitoring remains confined to physical signals. Exhaled breath condensate (EBC) harbors rich molecular information that could unveil diverse insights into an individual's health. Unfortunately, challenges related to sample collection and the lack of on-site analytical tools impede the widespread adoption of EBC analysis. Here, we introduce EBCare, a mask-based device for real-time in situ monitoring of EBC biomarkers. Using a tandem cooling strategy, automated microfluidics, highly selective electrochemical biosensors, and a wireless reading circuit, EBCare enables continuous multimodal monitoring of EBC analytes across real-life indoor and outdoor activities. We validated EBCare's usability in assessing metabolic conditions and respiratory airway inflammation in healthy participants, patients with chronic obstructive pulmonary disease or asthma, and patients after COVID-19 infection.
Keyphrases
- health information
- air pollution
- mental health
- end stage renal disease
- healthcare
- public health
- ejection fraction
- chronic obstructive pulmonary disease
- electronic health record
- particulate matter
- newly diagnosed
- chronic kidney disease
- gold nanoparticles
- physical activity
- machine learning
- prognostic factors
- risk assessment
- social media
- lung function
- ionic liquid
- pain management
- molecularly imprinted
- single cell
- health risk
- sleep apnea