Dipeptidyl Peptidase 4 Inhibition Stimulates Distal Tubular Natriuresis and Increases in Circulating SDF-1α1-67 in Patients With Type 2 Diabetes.
Julie A LovshinHarindra RajasekeranYulyia LytvynLeif E LovblomShajiha KhanRobel AlemuAmy LockeVesta LaiHuaibing HeLucinda HittleWeixun WangDaniel J DruckerDavid Z I CherneyPublished in: Diabetes care (2017)
DPP-4 inhibition promotes a distal tubular natriuresis in conjunction with increased levels of intact SDF-1α1-67. Because of the distal location of the natriuretic effect, DPP-4 inhibition does not affect tubuloglomerular feedback or impair renal hemodynamic function, findings relevant to using DPP-4 inhibitors for treating type 2 diabetes.