AMH and INSL3 in testicular and extragonadal pathophysiology: what do we know?

Andrea SansoneS KlieschAndrea M Isidori Stefan Schlatt

Published in: Andrology (2019)

Anti-Müllerian hormone and INSL3 are markers of Sertoli and Leydig cells maturation, respectively, usually involved in the pathogenesis of disorders of sexual differentiation. However, their role in testicular pathology has only been hinted at in the last decades. Recent evidence supports an involvement of both anti-Müllerian hormone and INSL3 in extragonadal pathophysiology as well.

Keyphrases

induced apoptosis
germ cell
cell cycle arrest
mental health
cell death
oxidative stress
cell proliferation