The novel μ-opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception.

Rob HillAlex DisneyAlex ConibearKaty SutcliffeWilliam DeweyStephen HusbandsChris BaileyEamonn KellyGraeme Henderson

Published in: British journal of pharmacology (2018)

These data demonstrate that PZM21 is a low efficacy μ receptor agonist for both G protein and arrestin signalling. Contrary to a previous report, PZM21 depresses respiration in a manner similar to morphine, the classical opioid receptor agonist.

Keyphrases

chronic pain
pain management
electronic health record
big data
deep learning