Chalcone-Based Synthesis of Tetrahydropyridazines via Cloke-Wilson-Type Rearrangement-Involved Tandem Reaction between Cyclopropyl Ketones and Hydrazines.
Yingfen MengJiayi GuMeixiu XinYi JiangZhibo DuGuoqing LuJiayao JiangAlbert Sun-Chi ChanZhuo-Feng KeYong ZouPublished in: The Journal of organic chemistry (2024)
A facile and efficient approach for the synthesis of multisubstituted tetrahydropyridazines starting from cyclopropyl ketones and hydrazines has been developed. The transformation is chalcone-based and takes place via a Cloke-Wilson-type rearrangement-involved tandem reaction catalyzed by TfOH in HFIP.