The first-year course of urine MCP-1 and its association with response to treatment and long-term kidney prognosis in lupus nephritis.
Abril A Perez-AriasR Angélica Méndez-PérezCristino CruzMaría Fernanda Zavala-MirandaJuanita Romero-DiazSofía E Márquez-MacedoRoque A Comunidad-BonillaC Carolina García-RuedaJuan Manuel Mejía-ViletPublished in: Clinical rheumatology (2022)
The first-year course of uMCP-1 is associated with response to therapy and kidney survival in LN. Key Points •Urine MCP-1 levels differentiate histologically-active lupus nephritis from histologically-chronic lupus nephritis •Urine MCP-1 levels decrease by 3 months of therapy in subjects with a favorable response whose kidney function remains stable long-term •Urine MCP-1 levels remain elevated during the first year of therapy in subjects the will later lose kidney function.