Deciphering the role of cDC2s in Sjögren's syndrome: transcriptomic profile links altered antigen processes with IFN signature and autoimmunity.

Ana P LopesMaarten R HillenAnneline C HinrichsSofie Lm BloklandCornelis Pj BekkerAridaman PanditAike A KruizeTimothy Rdj RadstakeJoel A van Roon

Published in: Annals of the rheumatic diseases (2022)

T cells, suggest altered antigen presentation by pSS cDC2s. These functional alterations were strongly linked to anti-SSA positivity and the presence of type I IFNs. Thus, we demonstrate novel molecular and functional pieces of evidence for the role of cDC2s in orchestrating immune response in pSS, which may yield novel avenues for treatment.

Keyphrases

immune response
cell cycle
dendritic cells
toll like receptor
disease activity
rna seq
systemic lupus erythematosus
smoking cessation