Association of Anti-Topoisomerase I Antibodies of the IgM Isotype With Disease Progression in Anti-Topoisomerase I-Positive Systemic Sclerosis.
Maaike BoonstraJaap Adriaan BakkerAnnette GrummelsMaarten K NinaberNina Ajmone MarsanCorrie M WortelTom W J HuizingaSuzana JordanAnna-Maria Hoffman-VoldAnastasiia KozlovaRené E M ToesHans Ulrich SchererJeska K de Vries-BouwstraPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2020)
In SSc patients who were anti-topo I IgG-positive, presence of anti-topo I IgM, which might be considered as a surrogate for an ongoing autoreactive B cell immune response, is associated with disease progression.