Analysis of the interaction effect of 48 SNPs and obesity on type 2 diabetes in Chinese Hans.

Jia LiuLu WangYun QianQian ShenHai ChenHongxia MaJuncheng DaiChong ShenGuangfu JinZhibin HuHongbing Shen

Published in: BMJ open diabetes research & care (2021)

Our findings indicated that the CDKN2A/CDKN2B gene-obesity interaction significantly increases T2D risk in Chinese Hans. The interaction effect identified in our study may help to explain some of the missing heritability in the context of T2D susceptibility. In addition, the interaction effect may play a role in the precise prevention of T2D in Chinese individuals.

Keyphrases

type diabetes
insulin resistance
metabolic syndrome
weight loss
genome wide
cardiovascular disease
high fat diet induced
glycemic control
physical activity
transcription factor