Association between APOA5 polymorphisms and susceptibility to metabolic syndrome: a systematic review and meta-analysis.
Sima MozafariMarziyeh AshooriSeyed Mahdi Emami MeybodiRoya SolhiSeyed Reza MirjaliliAli Dehghani FiroozabadiSepideh SoltaniPublished in: BMC genomics (2024)
The present findings suggest that polymorphisms located in the promoter and coding regions of the APOA5 gene are associated with an increased prevalence of MetS in the adult population. Identifying individuals with these genetic variations could lead to early disease detection and the implementation of preventive strategies to reduce the risk of MetS and its related health issues. However, because the sample size was small and there was evidence of significant heterogeneity for some APOA5 gene polymorphisms, these results need to be confirmed by more large-scale and well-designed studies.
Keyphrases
- metabolic syndrome
- healthcare
- genome wide
- copy number
- dna methylation
- public health
- primary care
- risk factors
- mental health
- gene expression
- single cell
- transcription factor
- insulin resistance
- uric acid
- quality improvement
- loop mediated isothermal amplification
- cardiovascular disease
- type diabetes
- real time pcr
- cardiovascular risk factors
- skeletal muscle
- adipose tissue
- genome wide identification
- social media
- quantum dots