Nanomechanical Characterization of Ovarian Cancer Cell Lines as a Marker of Response to 2c Treatment.
Domenico TiernoEros AzzaliniRossella FarraSara DrioliFulvia FellugaMarco LazzarinoGabriele GrassiBarbara DapasSerena BoninPublished in: International journal of molecular sciences (2023)
Epithelial ovarian cancers (EOCs) are a heterogeneous group of tumors with different molecular and clinical features. In past decades, few improvements have been achieved in terms of EOC management and treatment efficacy, such that the 5-year survival rate of patients remained almost unchanged. A better characterization of EOCs' heterogeneity is needed to identify cancer vulnerabilities, stratify patients and adopt proper therapies. The mechanical features of malignant cells are emerging as new biomarkers of cancer invasiveness and drug resistance that can further improve our knowledge of EOC biology and allow the identification of new molecular targets. In this study, we determined the inter and intra-mechanical heterogeneity of eight ovarian cancer cell lines and their association with tumor invasiveness and resistance to an anti-tumoral drug with cytoskeleton depolymerization activity (2c).
Keyphrases
- end stage renal disease
- chronic kidney disease
- newly diagnosed
- ejection fraction
- healthcare
- peritoneal dialysis
- prognostic factors
- papillary thyroid
- single cell
- squamous cell carcinoma
- emergency department
- patient reported outcomes
- induced apoptosis
- cell cycle arrest
- cell proliferation
- combination therapy
- electronic health record
- lymph node metastasis
- free survival
- adverse drug
- patient reported
- childhood cancer