Computer-aided analysis of quercetin mechanism of overcoming docetaxel resistance in docetaxel-resistant prostate cancer.

Victor Omoboyede Ochapa Ibrahim Haruna Isiyaku Umar Grace Ayomide Oke Olugbenga Samson Onile Prosper Obed Chukwuemeka

Published in: Journal, genetic engineering & biotechnology (2023)

Further analysis revealed epidermal growth factor receptor (EGFR) as the most pertinent target of quercetin in reversing DR in DRPC, while molecular docking simulation revealed an effective interaction between quercetin and EGFR. Ultimately, this study provides a scientific rationale for the further exploration of quercetin as a combinational therapy with docetaxel.

Keyphrases

epidermal growth factor receptor
molecular docking
tyrosine kinase
prostate cancer
advanced non small cell lung cancer
small cell lung cancer
locally advanced
single cell
molecular dynamics simulations
clinical trial
squamous cell carcinoma
radical prostatectomy
rectal cancer
mesenchymal stem cells