Login / Signup

Spiny mouse (Acomys): an emerging research organism for regenerative medicine with applications beyond the skin.

Janak GaireJustin A VarholickSabhya RanaMichael D SunshineSylvain DoréW Brad BarbazukDavid D FullerMalcolm MadenChelsey S Simmons
Published in: NPJ Regenerative medicine (2021)
The spiny mouse (Acomys species) has emerged as an exciting research organism due to its remarkable ability to undergo scarless regeneration of skin wounds and ear punches. Excitingly, Acomys species demonstrate scar-free healing in a wide-range of tissues beyond the skin. In this perspective article, we discuss published findings from a variety of tissues to highlight how this emerging research organism could shed light on numerous clinically relevant human diseases. We also discuss the challenges of working with this emerging research organism and suggest strategies for future Acomys-inspired research.
Keyphrases
  • wound healing
  • soft tissue
  • gene expression
  • endothelial cells
  • stem cells
  • current status
  • induced pluripotent stem cells
  • genetic diversity