Adipose mesenchymal stem cells combined with platelet-rich plasma accelerate diabetic wound healing by modulating the Notch pathway.

Nesrine EbrahimArigue A DessoukyOla MostafaAmira HassounaMohamed M YousefYasmin SeleemEman Abd El Aziz M El GebalyMona M AllamAyman Samir FaridBayan A SaffafDina SabryAhmed NawarAhmed A ShoulahAhmed H KhalilSami F AbdallaMohamed El-SherbinyNehal M ElsherbinyRabab F Salim

Published in: Stem cell research & therapy (2021)

These data demonstrated that PRP and ADSCs combined therapy significantly accelerated healing of diabetic wounds induced experimentally in rats via modulating the Notch pathway, promoting angiogenesis and EPSC proliferation.

Keyphrases

wound healing
platelet rich plasma
mesenchymal stem cells
signaling pathway
cell proliferation
high glucose
electronic health record
type diabetes
adipose tissue
umbilical cord
big data
endothelial cells
oxidative stress
cell therapy
drug induced
machine learning