Optical Genome Mapping for Comprehensive Assessment of Chromosomal Aberrations and Discovery of New Fusion Genes in Pediatric B-Acute Lymphoblastic Leukemia.
Huixia GaoHanli XuChanjuan WangLei CuiXiaotong HuangWeijing LiZhixia YueShuo TianXiaoxi ZhaoTianlin XueTianyu XingJun LiYing WangRuidong ZhangZhi-Gang LiTianyou WangPublished in: Cancers (2022)
OGM addresses some of the limitations associated with conventional cytogenomic testing. This all-in-one process allows the detection of most major genomic risk markers in one test, which may have important meanings for the development of leukemia pathogenesis and targeted drugs.
Keyphrases
- copy number
- acute lymphoblastic leukemia
- genome wide
- high resolution
- dna methylation
- small molecule
- acute myeloid leukemia
- allogeneic hematopoietic stem cell transplantation
- cancer therapy
- high throughput
- loop mediated isothermal amplification
- label free
- real time pcr
- bioinformatics analysis
- mass spectrometry
- genome wide identification
- drug delivery
- gene expression
- genome wide analysis
- sensitive detection