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Evaluating whole genome sequence data from the Genetic Absence Epilepsy Rat from Strasbourg and its related non-epileptic strain.

Pablo Miguel Casillas-EspinosaKim L PowellMingfu ZhuC Ryan CampbellJessica M MaiaZhong RenNigel C JonesTerence J O'BrienSlavé Petrovski
Published in: PloS one (2017)
This study highlights an approach for using whole genome sequencing to narrow down to a manageable candidate list of genetic variants in a complex genetic epilepsy animal model, and suggests utility of this sequencing design to investigate other spontaneously occurring animal models of human disease.
Keyphrases
  • endothelial cells
  • genome wide
  • copy number
  • oxidative stress
  • big data
  • machine learning
  • dna methylation
  • artificial intelligence
  • amino acid
  • high throughput sequencing