The combination of an inflammatory peripheral blood gene expression and imaging biomarkers enhance prediction of radiographic progression in knee osteoarthritis.
Mukundan AtturSvetlana KrasnokutskyHua ZhouJonathan SamuelsGregory ChangJenny BencardinoPamela RosenthalLeon RybakJanet L HuebnerVirginia B KrausSteven B AbramsonPublished in: Arthritis research & therapy (2020)
The use of the PBL inflammatory gene expression together with imaging biomarkers as combinatorial predictive biomarkers, markedly enhances the identification of radiographic progressors. The identification of the SKOA population at risk for progression will help in the future design of disease-modifying OA drug trials and personalized medicine strategies.