Knockdown of the stem cell marker Musashi-1 inhibits endometrial cancer growth and sensitizes cells to radiation.

Isabel Falke Fabian Martin TroschelHeike PalentaMaria T LöbleinKathrin BrüggemannKatrin BorrmannHans Theodor EichMartin GötteBurkhard Greve

Published in: Stem cell research & therapy (2022)

Musashi-1 knockdown resulted in a strong decrease in endometrial cancer proliferation and a loss of radioresistance, suggesting therapeutic potential.

Keyphrases

endometrial cancer
induced apoptosis
stem cells
signaling pathway
endoplasmic reticulum stress
cell cycle arrest
oxidative stress
cell death
dna damage response
pi k akt
radiation induced
cell proliferation
dna repair