The effects of hyperuricemia on endothelial cells are mediated via GLUT9 and the JAK2/STAT3 pathway.

Qian NieMiaomiao LiuZhimei ZhangXuemei ZhangChao WangGuangyao Song

Published in: Molecular biology reports (2021)

GLUT9 mediated the effects of high UA levels on HUVECs by increasing the cellular uptake of UA, activating JAK2/STAT3 signaling, and reduced the production of active eNOS and NO in HUVECs.

Keyphrases

endothelial cells
signaling pathway
uric acid
pi k akt
high glucose
vascular endothelial growth factor