Evaluation of Hydra HALT-1 as a toxin moiety for recombinant immunotoxin.

William F JiemyLih Fhung HiewHong Xi ShaLionel L A InJung Shan Hwang

Published in: BMC biotechnology (2020)

HALT-1 could be fused with anti-CD64-scFv via a fsexible polypeptide linker. Upon the successful production of this recombinant HALT-1 scFv fusion protein, HALT-1 was proven effective for killing two human cell lines. Hence, this preliminary study strongly suggested that HALT-1 holds potential as the toxin moiety in therapeutic cell targeting.

Keyphrases

escherichia coli
endothelial cells
cell free
induced pluripotent stem cells
mesenchymal stem cells
nk cells