Hypersensitive MR Angiography for Diagnosis of Ischemic Stroke and Reperfusion Subarachnoid Hemorrhage.
Peisen ZhangJunwei ChengChuang LiuWenyue LiYuqing WangNi ZhangJin WuXinyu ZhangChaoyong LiuYi HouPublished in: Analytical chemistry (2024)
Stroke is an acute injury of the central nervous system caused by the disorders of cerebral blood circulation, which has become one of the major causes of disability and death. Hemorrhage, particularly subarachnoid hemorrhage (SAH), is one of the poorest prognostic factors in stroke, which is related to the thrombolytic therapy, and has been considered very dangerous. In this context, the MR angiography with high sensitivity and resolution has been developed based on biocompatible paramagnetic ultrasmall NaGdF 4 nanoprobes. Owing to the appropriate hydrodynamic diameter, the nanoprobe can be confined inside the blood vessels and it only extravasates at the vascular injury site when the bleeding occurs. Relying on this property, the three-dimensional (3D) anatomic structures of artery occlusion of stroke rat can be precisely visualized; reperfusion-related SAH has been successfully visualized and identified. Benefiting from the long blood half-life of the nanoprobe, the observation window of MR angiography can last for the whole period of reperfusion, thereby monitoring the probable SAH in real time during thrombolytic therapy. More importantly, through reconstruction of multiparametric MRI, the arterial occlusion, cerebral ischemic region, and SAH can be simultaneously visualized in vivo in a 3D manner for the first time. Therefore, the current study provides a novel approach for both noninvasive 3D vascular visualization and hemorrhage alert, which possesses great prospects for clinical translation.
Keyphrases
- cerebral ischemia
- subarachnoid hemorrhage
- brain injury
- contrast enhanced
- optical coherence tomography
- prognostic factors
- computed tomography
- atrial fibrillation
- pulmonary embolism
- magnetic resonance
- magnetic resonance imaging
- blood brain barrier
- multiple sclerosis
- acute ischemic stroke
- living cells
- optic nerve
- respiratory failure
- bone marrow
- intensive care unit
- high resolution
- diffusion weighted imaging
- coronary artery disease
- stem cells
- single molecule
- fluorescent probe
- cell therapy
- photodynamic therapy
- left ventricular
- cerebral blood flow